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It is known that the human gut microbiome is different and stratified, not continuous, in the population

Improved Metabolic Function Lipedema is often associated with: Insulin resistance Impaired fat metabolism Mitochondrial dysfunction Emerging research suggests that lipedematous adipose tissue is metabolically inflexible, with reduced capacity for lipid mobilization and altered mitochondrial activity (Viana et al., 2025)

Whether the promising preclinical pharmacology will result in successful clinical trials is a question that will be answered in coming years

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Ozempic is used for ongoing treatment and has been studied for long-term use, while phentermine is only approved for short-term use because it can raise heart rate, blood pressure, and risk of dependence