Liu JJ, Huang Z, Zhang R, Zhang Q, Sun Z, Zhang Y, Liu B, Ma
Within the central nervous system, glutamate (Glu) functions as the primary excitatory neurotransmitter released from presynaptic terminals
293,294 This leads to mitochondrial calcium overload, causing cyclophilin D (CypD) to relocate from the mitochondrial matrix to the inner membrane, promoting the formation of the mitochondrial permeability transition pore (mPTP), further inhibiting ATP synthesis, activating oxidative stress, and apoptosis
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Campione E, Medda E, Patern EJ, et al