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Methyl-folate is a key player in this process

doi: 10.1016/j.ajpath.2015.12.004 237 BiedermannLMwinyiJScharlMFreiPZeitzJKullak-UblickGAet al

10.1021/acs.chemrestox.9b00268 80 YanS

However, it is important to specify that there are also conflicting data for HO-1 function in promoting anti-tumour processes since many other studies support a pro-tumour activity of HO-1 rendering this enzyme a double-faced molecule in cancer as well as Nrf2