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Both semaglutide and opioids slow gastric motility, meaning their combination can lead to severe constipation, bowel obstruction, or other serious GI complications

However there is a specific issue for women who are taking tirzepatide and who are relying on oral contraception to prevent pregnancy

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"For far too long, this disease has remained unrecognized, undiagnosed, and often untreated, despite impacting so many people." - Dave Moore, executive vice president of US Operations at Novo Nordisk You can read more about the approval here

Since its identification in the 1990s by the research group of Sikiric et al., it has become one of the most extensively studied peptides in tissue repair research, with published data spanning tendon healing, angiogenesis, nitric oxide regulation, and gastrointestinal cytoprotection