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PIP 3 also interacts with proteins possessing a pleckstrin homology (PH) domain, such as protein kinases, including Akt and Bruton's tyrosine kinase (BTK)

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It has been suggested, based largely on work in animal models, that enduring changes in GABA A Rs expression induced by developmental exposure to steroid hormones, such as progesterone and its metabolites play a role in hippocampal neuronal excitability and in the etiology of sex-dependent neuropsychiatric disorders and memory deficits later in life (209211)