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[36] Common lemons are the product of orange/citron hybridization, and hence have pomelo ancestry, and although Key limes are papeda/citron hybrids, the more commercially prevalent Persian limes and similar varieties are crosses of the Key lime with lemons, and hence likewise have pomelo ancestry

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It effectively lowers blood sugar levels, reducing the risk of complications associated with diabetes

2.3 Alteration of the gut microbiota With the emergence of advanced sequencing technologies, it has become apparent that metformin mitigates the imbalance in gut microbiota associated with T2DM and its subsequent impact on host metabolism

Theoretical concerns: angiogenic activity warrants caution in patients with active malignancy (no tumour-promoting effects observed in any preclinical study, but oncology populations have not been formally studied)