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Administration requirements: Must be taken fasting Small amount of water only Wait before eating or drinking Efficacy depends heavily on adherence to dosing instructions -Foundayo (orforglipron) is fundamentally different: Non-peptide small-molecule GLP-1 receptor agonist No SNAC absorption technology required Can be taken with or without food No fasting requirement No water restriction WEGOVY TABLET CHRONIC WEIGHT MANAGEMENT TRIALS OASIS 1 Oral semaglutide 50 mg once daily Adults with obesity or overweight without diabetes Duration: 68 weeks Mean weight loss: ~15.1% Adherent/trial-product analysis: ~17.4%~85% achieved 5% weight loss~54% achieved 15% weight loss OASIS 4 Oral semaglutide 25 mg once daily Duration: 64 weeks Mean weight loss: ~13.614% Improved waist circumference, blood pressure, and metabolic risk markers FOUNDAYO (ORFORGLIPRON) CHRONIC WEIGHT MANAGEMENT TRIALS ATTAIN-1 Adults with obesity or overweight without diabetes Duration: 72 weeks Orforglipron 6 mg:~7.8% mean weight loss Orforglipron 12 mg: ~9.3% mean weight loss Orforglipron 36 mg:~12.4% mean weight loss Approximately 12.4 kg average weight reduction After prior semaglutide therapy: Foundayo maintained ~79.3% of prior weight loss Placebo maintained ~37.6% APPROXIMATE WEIGHT-LOSS HIERARCHY -Foundayo/orforglipron:~7.812.4% -Wegovy tablet/oral semaglutide obesity doses:~13.615.1%

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Thyroid tumors have been noted in semaglutide studies on rodents

UK guidance advises stopping treatment immediately if pancreatitis is suspected and not restarting if confirmed

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