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What Happens When You Inject Cold Semaglutide: Safety Considerations Injecting semaglutide directly from a cold refrigerator (not frozen) is generally safe, though many patients find cold injections cause temporary stinging or localized numbness at the injection site

Pain during injection Some discomfort is expected with any injection

I felt like my head was clogged with thick syrup, and if I could just open a spigot and release it, Id feel better

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