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3.4.3.1 Neurobiological pathways The consumption of UPF may, in some cases, lead to the rewiring of the brain's reward systems, and these synaptic changes may replicate the types of changes that lead to reward and emotional dysfunction in substance use disorders (SUD) ( 3.4.3.2 Additives and palatability Additives in UPF, such as added salt, sugar and flavoring, increase the palatability of foods ( 3.4.3.3 Metabolic and hormonal pathways UPF has also been linked to changes in insulin sensitivity and satiety, which may also occur in the case of ED ( Some studies have shown that AN may be associated with reduced insulin sensitivity ( Other mechanisms that have been implicated as being important to the development of adverse metabolic effects include the maternal consumption of UPF, which may lead to changes in the fetal BBB, among individuals with ED ( Hence, these recent studies have demonstrated that UPFs have an important and multifaceted role in the onset and maintenance of ED, particularly in terms of the development of BED and BN

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Certain peptides, particularly BPC-157, stimulate angiogenesis, which is the formation of new blood vessels