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BMJ 305 : 14241429 Sachdev D, Li SL, Hartell JS, Fujita-Yamaguchi Y, Miller JS, Yee D (2003) A chimeric humanized single-chain antibody against the type I insulin-like growth factor (IGF) receptor renders breast cancer cells refractory to the mitogenic effects of IGF-I

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Therefore, PARP-1 activation seems to play an important role in the pathogenesis of PDN in several ways, likely including the regulation of various important inflammatory pathways

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