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Because growth hormone and IGF-1 support cell growth, there is a theoretical risk for individuals with active or past cancer

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While this is part of how they help with appetite and weight, it can also lead to: Acid reflux A feeling of fullness or pressure Disrupted sleep (especially if reflux worsens at night) Even if youve been taking Akkermansia, it may not fully offset this effect because the root issue here is mechanical (slower stomach emptying) rather than purely microbial

B12 form matters for both cost and patient tolerance