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The researchers also found that the levels of a substance called glutathione increased in the participants after being exposed to the cold

In addition, 2-oxoglutarate may also serve as a transcriptional modulator via activation of 2-oxoglutarate oxygenase, which has several biological roles, including demethylation of histones and nucleic acids, and destabilization of transcriptional factor HIF-1 42

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The NAD+-Dependent deacetylase SIRT1 modulates CLOCK-mediated chromatin remodeling and circadian control

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