Viking Therapeutics, a San Diego, California-based clinical-stage bio/pharmaceutical company, is advancing a dual GLP-1/GIP agonist, VK2735, for treating obesity for both subcutaneous and oral administration
Next-generation triple agonist treatments
also referred to as luteinizing hormone releasing hormone or LHRH) are diffusely located throughout the preoptic area and bed nucleus of the stria terminalis in rodents, and also in the arcuate nucleus of primates and guinea pigs
However, up to 10% undergoes bioactivation to N -acetyl p -benzoquinone imine (NAPQI), a highly reactive electrophile, which is known to covalently bind to nucleophilic centers, including cysteine thiols in liver proteins (see Figure 1) (Jollow et al., 2015)
Energy Metabolism: Enhances energy production by converting carbohydrates into glucose, which fuels the bodys activities