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Respiratory depression is the chief risk for elderly patients treated with opioids, and has occurred after large initial doses were administered to patients who were not opioid-tolerant or when opioids were co-administered with other agents that depress respiration

D., Freddo, A

HBV serves as a representative example: upon hepatocyte invasion, it establishes a persistent infection by forming covalently closed circular DNA in the nucleus, a stable transcriptional template that drives viral gene expression and replication