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In animal models finerenone reduced the expression of genes encoding monocyte chemoattractant protein-1, matrix metalloproteinase-2 and plasminogen activator inhibitor-1 (related to tissue remodelling and fibrosis) in the kidney, and additionally demonstrated beneficial immunomodulatory effects [73]
Int J Cancer 154:13771393
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The FDA-approved Wegovy label, for example, describes semaglutide as a GLP-1 receptor agonist used with reduced calories and increased physical activity for long-term weight reduction in certain adults and adolescents, and for reducing risk of major cardiovascular events in certain adults with cardiovascular disease and overweight or obesity
