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doi: 10.1016/j.celrep.2015.07.014 102 LochnerMBerodLSparwasserT

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In contrast, the bulkier Y37 rAmy in rAmy-bound AMY 2 R prevents equivalent interactions of N35 rAmy with RAMP2, and instead the bulkier Y37 rAmy forms interactions with E101 RAMP2 and F111 RAMP2 stabilising the peptide at the CTR/RAMP ECD interface in the bypass conformation

Beinaglutide treatment significantly reduces the visceral fat area and effectively improves insulin resistance, lowering the risk of hyperlipidaemia, diabetes, and cardiovascular disease [20, 21]