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Gut microbiota-derived gamma-aminobutyric acid from metformin treatment reduces hepatic ischemia/reperfusion injury through inhibiting ferroptosis

This group of compounds, associated with water-soluble-B complex vitamins, cannot be synthesized by mammalian cells

3 Oxidative stress Oxidative stress is a disbalance caused by excessive production of prooxidant substances such as ROS and RNS and/or the antioxidant systems working inefficiently (24, 25)

KPV also shows synergistic effects when combined with other peptides