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When tesamorelin is the more appropriate choice Tesamorelin is typically the preferred agent when: Visceral adipose tissue is the primary treatment target, particularly with associated metabolic comorbidities A clinician is working within a framework that prioritises FDA-approved agents The patient has HIV-associated lipodystrophy, the only approved indication A robust evidence base is required for clinical decision-making For general somatopause-related concerns gradual changes in body composition, sleep quality, and recovery the CJC-1295/ipamorelin combination remains more commonly used, primarily because of its flexible dosing profile and the preserved pulsatile GH release pattern

10.3945/ajcn.110.009340 117 ZhangZ.AtwellL

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After the exclusion of duplicates, 11 studies were screened, which included 5 cohort studies, 3 cross-sectional studies, and 3 case-control studies ( Table 1 )

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