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These effects enhanced the cytotoxicity of CD8+ T cells and their capacity to eliminate tumor cells, thereby augmenting the antitumor efficacy of PD-1 inhibitors (109,110)

J Diabetes Investig (2015) 6(5):495507

Melanin also is found in the retinal pigment epithelium (RPE), a single layer of epithelial cells located posterior to the photoreceptors in the retina

Target optimization, rational combination regimens, and dynamic biomarkers built around this pathway may break current therapeutic ceilings and deliver precise, durable clinical benefit