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In a 14-week extension study of Liraglutide Effect and Action in Diabetes 6 trial, patients switched from 10 g twice-daily exenatide to 1.8 mg liraglutide once-daily or 40 weeks of continued liraglutide

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This effect was likely due to attenuation of spinogenesis promoted by HGF and Dihexa treatments since, without the antagonizing effect of Hinge, each agonist increased mini-AMPA frequencies (Figure 13 A-B and Figure 10) thus forming functional synaptic connections