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In addition, in adipose tissue, lipolysis and lipogenesis are coupled as chronic stimulation of lipolysis activates lipogenesis to match adipose tissue catabolism with anabolism (151)

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MBOAT1 and MBOAT2 remodel PLs to protect cells from ferroptosis independent of GPX4

GPx activity varies by sample type and substrate, with the highest activity in erythrocytes, followed by liver, kidney, and serum

These results indicated that tumors with high ACTL6A expression, which rely more heavily on GSH metabolism than those with low ACTL6A expression, are more sensitive to ferroptosis inducers or GCLC inhibitors