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Leptin promotes glycolytic metabolism to induce dendritic cells activation via STAT3-HK2 pathway

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Premature discontinuation or non-adherence to the prescribed regimen could result in unmet therapeutic goals. Remember that the trials followed patients for over a year 68 weeks

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Failure of Lifestyle Monotherapy Lifestyle modification (LSM) is foundational but often insufficient for long-term weight maintenance in Class II or III obesity: Timing: Patients with a history of weight cycling (yo-yo dieting) are unlikely to achieve sustained success through behavioral interventions alone