Recent studies have demonstrated that plant-based nanoparticles generally exhibit superior biocompatibility and reduced systemic toxicity compared to chemically synthesized nanoparticles, largely due to the natural origin of their capping and stabilizing phytochemicals (170)
More physiologically relevant models, such as induced pluripotent stem cell-derived RPE (iPSC-RPE) and precision animal models, could help better mimic the progression of AMD and DR, thereby improving the translatability of preclinical findings
The clinical record must also explicitly state the precise anatomical site and the specific route of administration utilized
But the question would be, well, I exercise, I run, I do my high-intensity interval training, why do I need to get in the sauna
B12 has many functions in our body, so unfortunately a deficiency will give rise to a wide variety of symptoms, like brain fog, memory problems, cognitive impairment, insomnia, headaches, especially migraine, behavioural changes, learning problems, nominal aphasia, mood swings, irritability, depression, anxiety, hallucinations, delusions, psychosis, peripheral paraesthesia (pins and needles), numbness, neuropathic pains, poor balance, reduced vibration sense or proprioception (joint position sense), tinnitus, ataxia, taste impairment, sometimes myelopathy, fatigue, anaemia (either with larger red blood cells, or with normal size of the red blood cells when there is also iron deficiency), other reduction in blood cells, abdominal complaints, malabsorption, failure to thrive, weight loss, diarrhoea, hyperpigmentation, glossitis, (aphthous) stomatitis, infertility, urinary tract infections, joint and muscle pain, muscle weakness, spasticity, seizures, cardiomyopathy, urinary and/or faecal incontinence, postural hypotension/dizziness, erectile dysfunction, to name a few
