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Marchadier E, Oates ME, Fang H, Donoghue PCJ, Hetherington AM, Gough J

Those over the age of 50, where natural B-12 absorption declines

For a closer look at pairing retinol with the right supporting ingredients, our guide to retinol and hydration covers how to manage that adjustment period well, and our piece on retinol versus plant-based retinol (bakuchiol) is worth reading if the irritation profile of traditional retinol is what is giving you pause in the first place

Redman LM, Smith SR, Burton JH et al (2018) Metabolic slowing and reduced oxidative damage with sustained caloric restriction support the rate of living and oxidative damage theories of aging

Depending on the individual, monthly injections of B12 may be sufficient for some, while others may need more frequent doses