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Average weight loss with Contrave is approximately 5-8% of body weight, lower than tirzepatide but meaningful for people whose weight gain is driven by emotional eating, food addiction, or reward-seeking behavior patterns

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In the tirzepatide group, people had an average of 30.4 fewer apnea events per hour, compared to an average reduction of six events per hour in the placebo group

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While tirzepatide dramatically reduces hunger, some researchers still consume calorie-dense low-nutrient foods when they do eat