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10.1016/j.biopha.2022.114020 623

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Introduction Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS) or Systemic Exertion Intolerance Disease (SEID) ( ME/CFS impacts all ages, races, and socioeconomic groups ( Due to the disabling symptoms which include cognitive and physical impairment worsened by exertion ( In this review paper, we will focus on describing ME/CFS in terms of symptoms, severity and burden, diagnostic criteria, causes and triggers