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Even "non-sedating" second-generation antihistamines can cause fatigue, cognitive impairment, and what many describe as "brain fog." 2 Research has shown that chronic use of first-generation antihistamines is associated with concerning effects, including memory problems

[PubMed: 10744772] 623

But know this: Having a genetic mutation might put you at increased risk, but its only one check in the risk column

These include immunogenicity associated with certain ligands, restricted tissue penetration due to the tumors dense extracellular matrix, and dynamic regulation of receptor expression that can hinder consistent targeting

Diabetes mellitus associated with cystic fibrosis