"I certainly think they are useful and can think of many situations where they decrease risks of heart disease, stroke, diabetes and cancer as well as the need for bariatric surgery but they are surely not one-size-fits-all and are mostly not first-line therapy." Are all GLP-1s created equal
Atherosclerosis (2013) 230:1917
This is the second large and under-discussed divergence between the DSIP literature and contemporary practice, and it compounds the dose gap described above
Specifically, ACSL4 has a preference for long-chain polyunsaturated fatty acids, such as arachidonic acid (AA) or adrenergic acid (Ada) [54, 55], and converts them to arachidonic CoA and adrenal CoA, respectively, which are more likely to be oxidized to form lipid peroxides [56, 57]
These typically appear in weeks 1 to 4