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Diabetologia 62 , 17121726 (2019)

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Its derivative, phenylbutyric acid, exhibits similar protective effects, including maintenance of antioxidant enzyme activity via inhibition of mitochondrial ROS accumulation and HO release, reduction of myocardial apoptosis through downregulation of iNOS/nitrotyrosine expression, and attenuation of collagen deposition by inhibiting the CTGF/MMP-2 pathway (Russo et al., 2019)