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Bacteria cultured from this site included Staphylococcus aureus , Klebsiella pneumoniae , and gas-producing coliforms, although other laboratory tests showed no significant abnormalities

Specifically, hypoxia induces a decrease in claudin 5 and occludin protein levels, which increases the paracellular diffusion of solutes and ions across the BBB (Andersson et al., 2021)

doi: 10.1080/02648725.2022.2082157

In individuals with IBD, proinflammatory cytokines downregulate OCTN2 through the PPAR/RXR pathway, resulting in reduced carnitine uptake by intestinal epithelial cells that leads to the dysfunction of intestinal regeneration and repair and further deterioration of IBD [232]