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Efficacy of an oral lipid nanocrystal formulation of amphotericin B (MAT2203) in the neutropenic mouse model of pulmonary mucormycosis

A statistically significant increase in thyroid C-cell adenomas was observed in males (0.5 mg/kg) and females (0.15 mg/kg), and a statistically significant increase in thyroid C-cell adenomas and carcinomas combined was observed in males and females at all doses examined

Direct head-to-head comparisons across the three compounds remain an active area of preclinical and clinical research investigation