Identical trends were observed for internalization rate, calculated as the build-up of cytoplasmic fluorescence intensity over time (mean internalization rate: vehicle = 85.8 76.1 min 1 , Ex4 = 213.0 140.5 min 1 , Ex9 = 89.2 104.1 min 1 , semaglutide = 126.6 101.5 min 1 , tirzepatide = 135.4 102.5 min 1
L., Haluzk, M., & PIONEER 1 Investigators
Risinger maintained Leerinks Market Perform rating on Lilly shares
Approved uses and dosing context Across the class, FDA-approved indications include type 2 diabetes for most compounds, chronic weight management for Wegovy, Saxenda, and Zepbound, and obstructive sleep apnea in adults with obesity for Zepbound as of 2024
GLP-1 medications are already influencing how people eat, what they buy, and what they expect from food