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Human trials followed, and the results have been consistent: people drink less, drink less often, and report fewer cravings

People with low B12 may experience: Persistent fatigue or low energy Weakness Brain fog, concentration issues, or memory changes Low mood or irritability Pins and needles, numbness, or nerve-type sensations Mouth ulcers or a sore tongue Paleness or shortness of breath (if anaemia is present) Some symptoms can become more serious if deficiency is prolonged, particularly neurological symptoms

These numbers compare well to other treatments

Neuron 112 , 14161425 (2024)

Standard newborn screening tests include detection of holocarboxylase synthetase deficiency by analysis of blood for the presence of elevated O-(3-hydroxyvaleryl)-L-carnitine