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The review concluded that NNMT plays important roles in obesity and type 2 diabetes and validated 5-Amino-1MQ as a potent small-molecule NNMT inhibitor that reverses diet-induced metabolic changes, establishing it as a primary research tool for the NNMT pathway

[3] This chelation-and-delivery role is the mechanistic seed from which most downstream effects grow, and it is intrinsic to the molecule regardless of how it is administered

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Wang J, Chin D, Poon C, Mancino V, Pham J, Li H, Ho P-Y, Hallows KR, Chung EJ (2021) Oral delivery of metformin by chitosan nanoparticles for polycystic kidney disease

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