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GLP-1R agonists show great potential in AD, but key challenges, such as blood brain barrier (BBB) penetration, clinical trial inconsistency, long-term safety and precision therapy, need to be addressed

Eligible studies consisted of randomized controlled trials (RCTs) involving adults with T2DM that lasted at least eight weeks and compared twice-daily Exenatide (EBID), once-weekly Exenatide (EQW), Semaglutide, Albiglutide, Lixisenatide, Dulaglutide, Liraglutide, or Tirzepatide against one another, placebo, or conventional antidiabetic therapies such as insulin, metformin, sodium-dependent glucose transporter 2 inhibitors, dipeptidyl peptidase-4 inhibitors, or sulfonylureas

INTRODUCTION The first incretin hormone, gastric inhibitory peptide, was identified in the early 1970s, followed by the discovery of glucagonlike peptide 1 (GLP-1) in the 1980s [1]

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