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doi: 10.3389/fcell.2022.954186 75 XieFZhangJZhaiMLiuYHuHYuZet al

Mechanistically, microbiota-derived short-chain fatty acids (SCFAs) regulate epithelial barrier function and mucosal immunity via evolutionarily conserved mechanisms involving G protein-coupled receptor signaling and histone deacetylase (HDAC) activity

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To aid in the creation of conceptual figures, we used OpenAIs ChatGPT (OpenAI, accessed on 15 June 2025) and BioRender ( accessed on 20 June 2025) to generate draft illustration layouts, which were subsequently edited by the authors for accuracy and clarity