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Emerging liquid biopsy tools, such as circulating free DNA and microRNAs, offer promise as minimally invasive biomarkers, yet remain in the exploratory stage due to limited sensitivity, specificity, and validation in large cohorts (154)

By targeting the receptor rather than the ligand, bimagrumab blocks multiple growth-inhibiting signals simultaneously, including myostatin, activin A, and GDF-11

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Furthermore, GEN are reported to induce liver cancer MHCC97-L cells apoptosis and activity of caspase-3 and caspase-9 through inhibiting JNK pathway (Liu et al., 2019)

Pathophysiology of anaemia: focus on the heart and blood vessels