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3 However, at pharmacological doses, GIP agonism appears to increase fat oxidation by promoting futile calcium cycling, thereby diminishing the metabolic adaptation often observed with weight loss

When to Consult Your Doctor About Persistent Fatigue While some fatigue during the adjustment period is normal, persistent or severe tiredness warrants a conversation with your healthcare provider

and Supplementary Table 1)

Monitoring : Patients using both substances should be monitored more closely for treatment efficacy (weight loss progress), adverse effects (particularly gastrointestinal symptoms), and overall wellbeing

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