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Overall survival comparisons were performed by KaplanMeier analysis using log-rank testing for patients separated based on the mean OxPhos score generated using single-sample GSEA

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Accordingly, NP design and experimental studies should explicitly balance benefits against risks to maximize clinical effectiveness while prioritizing patient safety

Compared with other forms of cell death such as apoptosis, necrosis, and autophagy, ferroptosis exhibits distinct molecular mechanisms and biological features ( Table 1 ): (1) Iron Dependence: Ferroptosis is uniquely triggered by elevated intracellular iron levels, differentiating it from other cell death modes

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