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Additionally, their impact on cardiovascular outcomes is still under investigation

In addition to mechanical distention, the chemical stimulation of receptors in gastro-intestinal mucosa and various hormones released from the gastrointestinal mucosa by nutrients, contribute to the peripheral signaling from gastrointestinal tract and pancreas with orexigenic as well as anorexigenic properties ( Fig

Reduced kidney function and folate status are major confounders, since both can raise MMA and/or homocysteine independently of B12

Paying attention to regular fluids and balanced nutrition can help

This depends on how well the body responds and what it needs