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and high-frequency synaptic transmission imposes further metabolic burdens [63]
This multi-receptor mechanism distinguishes it from earlier weight-management medicines such as semaglutide (Wegovy) or tirzepatide (Mounjaro), and it also explains why gastrointestinal effects including changes to bowel habits are among the most frequently reported experiences in clinical trials
Semaglutide, a potent medication belonging to the class of glucagon-like peptide-1 receptor agonists (GLP-1 RAs), has revolutionized treatment protocols and reshaped patient outcomes
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