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As excess weight creates an imbalance in these substances, your risk of developing the following conditions increases: Diabetes Heart disease High cholesterol High blood pressure Obstructive sleep apnea Endometrial, breast, prostate and colon cancers Why is it hard to lose weight

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"Pernicious" means "harmful" or "destructive." This type of B12 deficiency anemia can affect many body systems and cause problems in your gut, heart, and muscles