Topiramate did not affect BP in either strain but significantly reduced SD susceptibility in WKY rats, with no effect in SHR rats
Before prescribing a GLP-1 peptide, a responsible doctor must screen for specific contraindications
"The use of weight loss jabs in a context where thinness is already put on a pedestal and where eating disorders and disordered eating is already a concern, is a recipe for disaster," said Dr Garcia Ashdown-Franks, research fellow at York St John University
These drugs also appear to have major pleiotropic effects in CV risk reduction, (STEP trials , SELECT trial, STEP HFpEF, SCRIBE, SUMMIT, SURMOUNT-MMO (completion 2027)) reversal of metabolic dysfunctionassociated steatotic liver disease (MASLD), previously known as non-alcoholic fatty liver disease (SYNERGY NASH MASH), and non-progression if not reversal of chronic kidney disease (CKD) (FLOW trial)
This effect may help slow the progression of liver-related conditions