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Appetite Suppression: Helps reduce overall calorie intake by targeting brain signals that control hunger and fullness

Rizzo M, Abate N, Chandalia M, Rizvi AA, Giglio RV, Nikolic D, et al

The two main peptides that fulfill criteria for an incretin are the intestinal peptide glucagon-like peptide-1 (GLP-1) and gastric inhibitory peptide (GIP, also known as: glucose-dependent insulinotropic polypeptide)

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161 Over a period of 24 weeks, all dosage groups of retatrutide showed significant improvements in reducing glycated hemoglobin (HbA1c) and body weight compared to the placebo group, especially in the higher dosage groups