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Creatine , a compound stored in muscle and brain that buffers the cells energy supply through the phosphocreatine system, is warranted for performance under metabolic stress, sleep deprivation in particular
867 HSPA5, member A of the heat shock protein family, directly binds to GPX4 and positively regulates its expression
In senescence microglia, lactate concentration is elevated, and IB, a negative regulator of NF-B, is phosphorylated and subsequently degraded, leading to activation of the NF-B pathway (Wei L
Inhibition of System Xc blocks cystine import, disrupting GSH synthesis, impairing cellular antioxidant capacity, and inactivating GPX4, ultimately driving intracellular ROS accumulation and cell death
Internet J Endocrinol
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