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The rate-limiting enzyme in GABA synthesis, GAD, is found only in neurons, thus establishing this cell type as the likely primary site of estradiol action where it increases the activity of GAD, and thereby the synthesis of GABA, which is released from neurons to act on neighboring astrocytes to induce stellation

[DOI] [PMC free article] [PubMed] [Google Scholar] 45.Ibi A., Chang C., Kuo Y.C., Zhang Y., Do P., Du M., Roh Y.S., Gahler R., Hardy M., Solnier J

(18) Inflammatory Bowel Diseases Not to be confused with IBS, Inflammatory Bowel Disease (IBD) can cause inflammation and permanent harm to the colon

ROS mediates lipid peroxidation, which leads to tissue damage development after MTX administration