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Vitamin B12 deficiency is the dominant nutritional cause of hyperhomocysteinemia in a folic acid-fortified population

On average, 1 to 2 syringes per hand are needed for a noticeable improvement, though some may require more

Autonomic neuropathy Another neuropathic complication of diabetes mellitus is cardiac autonomic neuropathy (CAN), which occurs in as many as 25% of diabetic patients (55)