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GSH moderates the ISR gene expression during cystine starvation Activation of the ISR elevates ATF4 to increase expression of genes which contain the amino acid response elements (AARE) 16

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Author contributions TD designed and conducted the experiments and wrote the manuscript

This peptide discovered in 1973 by Pickart, has the highest concentration in young adults (age 25 and younger), when tissues have the most regenerative potential