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Over the past decade, it has been demonstrated that myocardial structure, cardiomyocyte function, and intramyocardial signaling undergo specific alterations in heart failure with preserved ejection fraction (HFpEF)

Alternative diabetes or weight management therapies should be considered in consultation with specialist services

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Patient selection should consider contraindications, including personal or family history of medullary thyroid carcinoma or Multiple Endocrine Neoplasia syndrome type 2 (boxed warning), and hypersensitivity to semaglutide or any product components