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Albiglutide was less effective in activating the GLP-1R compared to exendin-4 in an in vitro study of a BHK cell line expressing the rat GLP-1R (92)

47 These symptoms are due to the drugs mechanisms of action, particularly delayed gastric emptying, and are the primary reason for treatment discontinuation, representing a major barrier to adherence

Efficacy and safety of once-weekly semaglutide versus once-daily insulin glargine as add-on to metformin in insulin-naive patients with type 2 diabetes (SUSTAIN 4): A randomized, open-label, parallel-group, multicenter, multinational, phase 3a trial

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